Target identification with optical feedback signal splitter

ABSTRACT

A probe of a target identification system can be extended via a first lumen of a viewing instrument, such as for illuminating an area beyond a distal end of the viewing instrument via an optical path of the viewing instrument. An optical response to the illumination of the area can be received via an optical path of the probe and can be split from other optical signals of the optical path. The optical response information can be used to identify characteristics of a target and to adjust parameters of a working instrument such as a working instrument contemporaneously using the probe.

CLAIM OF PRIORITY

This application claims the benefit of priority under 35 U.S.C. § 119(e)of U.S. Provisional Patent Application Ser. No. 62/882,837, filed onAug. 5, 2019, U.S. Provisional Patent Application Ser. No. 62/931,360,filed on Nov. 6, 2019, U.S. Provisional Patent Application Ser. No.63/008,940, filed on Apr. 13, 2020, and U.S. Provisional PatentApplication Ser. No. 63/018,262, filed on Apr. 30, 2020, which areherein incorporated by reference in their entireties.

FIELD OF THE DISCLOSURE

The documents relates generally to optical surgical system, and moreparticularly to techniques for target identification using an opticalresponse signal sharing a pathway with another optical signal.

BACKGROUND OF THE DISCLOSURE

Laser or plasma systems have been used for delivering surgical laserenergy to various target treatment areas such as soft or hard tissue.Examples of the laser therapy include ablation, coagulation,vaporization, fragmentation, etc. In lithotripsy applications, laser hasbeen used to break down calculi structures in kidney, gallbladder,ureter, among other stone-forming regions, or to ablate large calculiinto smaller fragments.

Endoscopes are typically used to provide access to an internal locationof a subject such that a physician is provided with visual access. Anendoscope is normally inserted into a patient's body, delivers light toa target (e.g., a target anatomy or object) being examined, and collectslight reflected from the object. The reflected light carries informationabout the object being examined. Some endoscopes include a workingchannel through which the operator can perform suction or passinstruments such as brushes, biopsy needles or forceps, or performminimally invasive surgery to remove unwanted tissue or foreign objectsfrom the body of the patient.

In certain procedures employing electromagnetic energy, there is no wayof identifying composition of a target while executing the procedure.For health-related procedures, it can be difficult to identify whether atarget is soft or hard tissue in vivo. There are some surgical methodsthat can be used to extract tissue and then identify the composition ofthe tissue once it has been removed from the body, but tissuecomposition cannot be determined in vivo.

BRIEF DESCRIPTION OF THE DRAWING

FIG. 1 illustrates generally an example target identification systemwithin a surgical system such as an ablation system.

FIG. 2 illustrates generally a detailed example of a targetidentification system.

FIG. 3 illustrates generally an example of a beam splitter within anexample target identification system.

FIG. 4 illustrates generally a detailed example of a beam splitterwithin an example target identification system.

FIG. 5 illustrates generally a detailed example of a beam splitterwithin an example target identification system.

FIG. 6 illustrates generally an example of a method of operating anablation system.

FIG. 7 illustrates generally an example of a beam splitter within anexample target identification system.

FIG. 8 illustrates generally an example of a beam splitter within anexample target identification system.

FIG. 9 illustrates generally an example of a beam splitter within anexample target identification system.

SUMMARY

Techniques are provided for determining a composition of a target whileperforming a procedure to the target. For ease of understanding, thetechniques are described in terms of health-related procedures but arenot so limited. Techniques are provided for determining a composition oftissue in vivo (internal to a patient) such as while conducting amedical procedure at or near the tissue. As an example, for ablation ofobstructive tissue such as renal calculi, tissue composition informationcan assist in executing the procedure more efficiently and effectively.The present techniques can include or use a system comprising a viewinginstrument including a lumen, a working instrument, a light source, abeam splitter, and a laser light source. The viewing instrument caninclude an endoscope or a laparoscope, such as can define a proximal endand a distal end. The working instrument can include a working probe,such as can extend through the lumen of the viewing instrument. Thelight source can illuminate an area beyond the distal end of the viewinginstrument, such as by providing illumination via an optical path of theviewing instrument. The beam splitter can be located at or coupled to aproximal end of the optical path of the working instrument. The laserlight source can be coupled to the beam splitter and can generate alaser beam. The laser beam can pass from a proximal end of the workinginstrument to a distal end of the working instrument, such as via theoptical path of the working instrument. The optical path of the workinginstrument can optionally pass an optical response signal received fromthe area beyond the distal end, such as for communication from thedistal end of the working instrument to the beam splitter located at theproximal end of the working instrument.

Example 1 is a target identification system comprising: a probe having afirst end and a second end, the second end configured to locate adjacentan anatomical target, the probe configured to define an optical path,the optical path configured to simultaneously pass a first opticalsignal and a second optical signal representative of the anatomicaltarget; and a beam splitter comprising: a first port coupled to thefirst end of the probe; a second port configured to align with theoptical path and configured to pass the first optical signal; andwherein the beam splitter is configured to redirect the second opticalsignal representative of the anatomical target from the optical path andfrom the first optical signal.

In Example 2, the subject matter of Example 1 optionally includes aspectrometer optically coupled to the beam splitter, the spectrometerconfigured to receive from the beam splitter the second optical signalrepresentative of the anatomical target and to provide spectralmeasurements representative of the anatomical target.

In Example 3, the subject matter of Example 2 optionally includes afeedback analyzer configured to receive the spectral measurements and togenerate a composition profile of the target.

In Example 4, the subject matter of any one or more of Examples 2-3optionally includes, wherein the beam splitter includes: a focusinglens; an optical sensor; and wherein the focusing lens includes awavelength sensitive layer, the wavelength sensitive layer configured topass the first optical signal along the optical path and to redirect thesecond optical signal toward the optical sensor.

In Example 5, the subject matter of Example 4 optionally includes,wherein the optical sensor is configured to couple to the spectrometerand to convert the second optical signal to one or more electricalsignals.

In Example 6, the subject matter of any one or more of Examples 2-5optionally includes, wherein the beam splitter includes: a focusing lenshaving a wavelength sensitive layer, the wavelength sensitive layerconfigured to pass the first optical signal along the optical path andto redirect the second optical signal; a third optical port coupled tospectroscopic system; and an integrating sphere configured to furtherredirect the second optical signal to the third optical port.

In Example 7, the subject matter of any one or more of Examples 2-6optionally includes, wherein the beam splitter includes: a third opticalport; and a dichroic mirror configured to pass the first optical signalfrom the first port to the second port, and to redirect the secondoptical signal to a third optical port.

Example 8 is a surgical system comprising: a viewing instrumentincluding a lumen, the viewing instrument and the lumen defining aproximal end and a distal end, the viewing instrument comprising a lightsource configured to illuminate an anatomical target via an optical pathof the viewing instrument; and a target identification systemcomprising: a working probe configured to extend through the lumen; abeam splitter coupled to a proximal end of the working probe, the beamsplitter configured to split an optical response signal indicative ofthe target from the optical path; and a spectrometer optically coupledto the beam splitter, the spectrometer configured to receive from thebeam splitter at least a representation of the optical response signaland provide spectral measurements representative of the anatomicaltarget.

In Example 9, the subject matter of Example 8 optionally includes,wherein the beam splitter includes: a first port coupled to the proximalend of the probe; and a second port configured to align with the opticalpath and configured to pass a second optical signal.

In Example 10, the subject matter of Example 9 optionally includes,wherein the beam splitter includes: a focusing lens; an optical sensor;and wherein the focusing lens includes a wavelength sensitive layer, thewavelength sensitive layer configured to pass the second optical signalalong the optical path and to redirect the optical response signaltoward the optical sensor.

In Example 11, the subject matter of Example 10 optionally includes,wherein the optical sensor is configured to couple to the spectrometerand to convert the optical response signal to one or more electricalsignals.

In Example 12, the subject matter of any one or more of Examples 9-11optionally includes, wherein the beam splitter includes: a focusing lensin a path of the optical path, the focusing lens including a wavelengthsensitive layer, the wavelength sensitive layer configured to pass thesecond optical signal along the optical path and to redirect the opticalresponse signal to provide a redirected optical response signal; a thirdoptical port coupled to spectrometer; and an integrating sphereconfigured to reflect the redirected optical response signal to thethird optical port.

In Example 13, the subject matter of any one or more of Examples 9-12optionally includes, wherein the beam splitter includes: a third opticalport coupled to the spectrometer; and a dichroic mirror configured topass the second optical signal along the optical path, and to reflectthe optical response signal to the third optical port.

In Example 14, the subject matter of any one or more of Examples 8-13optionally includes, wherein the target identification system includes afeedback analyzer configured to receive spectral information and togenerate a composition profile of the target.

In Example 15, the subject matter of Example 14 optionally includes aprocedure instrument configured to utilize the working probecontemporaneously with the optical response signal transiting theoptical path; and wherein the feedback analyzer is configured to providecontrol signals to the procedure instrument based on the compositionprofile.

In Example 16, the subject matter of Example 15 optionally includes,wherein the procedure instrument includes a laser configured to generatea laser beam, the laser beam configure to transit the optical path fromthe beam splitter to the distal end of the probe contemporaneously withthe optical response signal transiting the optical path.

Example 17 is a laser surgery system comprising: a laser systemconfigured to generate a laser beam operable to ablate a target within apatient's body; an optical probe comprising: an optical fiber configuredto transmit the laser beam to the target and to transmit target lightfrom the target; and a beam splitter configured to pass the laser beamfrom the laser system to the optical fiber and to receive the targetlight and split the target light from the laser beam; a spectrometeroptically coupled to the beam splitter, the spectrometer configured toreceive the target light split from the laser beam and to generatespectral information of the target light; and feedback circuitryconfigured to receive the spectral information and determine compositioninformation of the target.

In Example 18, the subject matter of Example 17 optionally includes,wherein the laser system is configured to receive the compositioninformation and to adjust the laser beam responsive to the compositioninformation.

Example 19 is a method comprising: extending a working instrument via afirst lumen of a viewing instrument; illuminating an anatomical targetvia an optical path of the viewing instrument; passing an opticalresponse signal of the anatomical target via an optical path of theworking instrument; and splitting the optical response signal from theoptical path of the working instrument.

In Example 20, the subject matter of Example 19 optionally includes,wherein the viewing instrument is an endoscope.

In Example 21, the subject matter of any one or more of Examples 19-20optionally includes, wherein the viewing instrument is a laparoscope.

In Example 22, the subject matter of any one or more of Examples 19-21optionally include passing the optical response signal to a spectroscopysystem.

In Example 23, the subject matter of any one or more of Examples 19-22optionally include passing a second optical signal via the optical pathof the working instrument at while passing the optical response signal.

In Example 24, the subject matter of Example 23 optionally includes,wherein the second optical signal is a laser beam configured to ablatethe anatomical target.

In Example 25, the subject matter of Example 24 optionally includes,wherein passing the optical response signal to a spectroscopy systemincludes splitting the optical response from the optical path of theworking instrument to a third optical path.

In Example 26, the subject matter of Example 25 optionally includes,wherein passing the laser beam includes merging an optical pathextending from the laser with the optical path of the workinginstrument.

In Example 27, the subject matter of Example 26 optionally includes,wherein merging an optical path extending from the laser includespassing the laser beam through a dichroic mirror; and wherein splittingthe optical response from the optical path of the working instrumentincludes reflecting the optical response a surface of the dichroicmirror.

This section is intended to provide an overview of subject matter of thepresent patent application. It is not intended to provide an exclusiveor exhaustive explanation of the invention. The detailed description isincluded to provide further information about the present patentapplication.

DETAILED DESCRIPTION

Identifying the composition of tissue in vivo via an endoscope orlaparoscope has numerous applications. For example, if the compositionof a renal calculus could be determined a priori, the treatment methodcould be based at least in part on the composition of the stone. Forexample, when using a laser to break-up or “dust” a stone, if it wereknown a priori that the stone had a hard composition, then the lasersettings could be adjusted to settings that perform better on a hardkidney stone.

Also, techniques that require the removal of a tissue sample to identifythe composition cannot monitor the composition of the tissue on anongoing basis through all or a portion of entire procedure. The presenttechniques can allow measurement and analysis of the composition of ananatomical target, or target tissue, at the tip of the endoscope orlaparoscope. These techniques can provide more information during ahealth related procedure, such as a surgical or diagnostic procedure, tobetter adapt a treatment method during the procedure. For example, if aprocedure involves breaking a renal calculus into tiny pieces, e.g.,“dusting” the renal calculi, that has a hard surface, but a soft core,the continuous or other ongoing monitoring of the target tissuecomposition via the endoscope or laparoscope can allow adjustment of,for example, the settings of the instrument doing the “dusting” duringthe procedure, such as laser settings for a laser ablation instrument.The identification of the target tissue can allow for first providingsettings that perform better on the hard surface of the stone to thenproviding settings that perform better on the soft core of the stone.

FIG. 1 illustrates generally an example target identification system 100within a surgical system 110 such as an ablation system. The surgicalsystem 110 can include visualization equipment such as an endoscope 101,the target identification system 100, and primary medical equipment suchas a laser ablation system 102. The endoscope 101 can include anendoscope probe 103, a laser or other light source 104 and a displayassembly 105. The endoscope probe 103 can include a camera 106, one ormore optical signal communication pathway 107, 108, and at least oneworking lumen 111. A distal portion of the endoscope probe 103 can beinserted within a patient's body. The light source 104, one or moreoptical transmission media 107, 108, and display assembly 105 can allowan end-user, such as a physician or surgeon or robotic device, toilluminate and observe an internal area of the patient's body at or nearthe distal end 109 of the endoscope probe 103. For example, the lightsource 104 can illuminate the area at or beyond the distal end 109 ofthe endoscope probe 103 via a first optical transmission media 108, anda second optical transmission media 107 can communicate image signalinformation from the camera at the distal end 109 of the endoscope probe103 to signal processing circuitry at the display 105 for displaying animage of the area at or beyond the distal end 109 of the endoscope probe103. In some examples, the second optical or electrical transmissionmedia 107 can include one or more components such as one or more opticalfibers and the display 105 can include an eyepiece for the end-user toobserve the area at or beyond the distal end 109 of the endoscope probe103. In certain examples, the second optical transmission media 107 cancouple viewing image signal information from the camera 106 to anelectronic display 105 such as for the end-user to observe the area ator beyond the distal end 109 of the endoscope probe 103. In someexamples, the camera 106 can be located at or near the proximal end ofthe endoscope probe 103, such as near the display 105, and one or moreoptical fibers can form the second optical transmission media 107 totransmit the image information from the distal end 109 of endoscopeprobe 103 to the camera 106. In some examples, the camera 106 can belocated at the distal end 109 of the endoscope probe 103, and imageinformation can be transmitted to the display 105 via electricalconductors forming the second optical transmission media 107 integratedwith the endoscope probe 103.

The working lumen 111 can further allow the end-user to insert andextract a portion of the primary medical instrument such as one or moresurgical tools for operating about the targeted internal region of thepatient's body being visualized using the endoscope probe 103. Forexample, for a surgical ablation system 102, the primary medicalinstrument can include a working probe 113 and a laser 112 to allowablation of tissue at or near the distal end 109 of the endoscope probe103. In such a system, for either endoscopic or laparoscopic procedures,a laser beam 118 can pass energy through the working lumen 111 toeffectively treat hard and soft tissue. In certain examples, the lasersystem 102 can produce a laser output beam 118 in a wide wavelengthrange from ultraviolet (UV) to infrared (IR) (e.g., 200 nm to 10000 nm).Some lasers can produce an output in a wavelength range that can behighly absorbed by soft or hard tissue, for example 1900-3000 nm forwater absorption or 400-520 nm for oxy-hemoglobin and/ordeoxy-hemoglobin absorption.

The working probe 113 may also be a part of the target identificationsystem 100. The target identification system 100 can include the workingprobe 113, an optical beam splitter 114, and a spectroscopy system 115.The spectroscopy system 115 can include a spectrometer 128 and anoptional feedback analyzer 116. The target identification system 100 canuse image response information such as content of electromagneticemissions, either reflected or radiated from a target, to assist indetermining a material or composition of the target, such as targettissue. Such electromagnetic emissions can include, but is not limitedto, light visible to the human eye, florescent emissions, ultra-violetlight, infrared light, or combinations thereof.

In certain examples, such image response information can be used to moreefficiently execute a procedure. In an example, light from the lightsource 104 can reflect off the target tissue 117 or can cause the targettissue to emit optical information, such as by florescence, for example.Such optical information is referred to herein as image responseinformation or optical response information conveyed for example via anoptical response signal 119. The spectrometer 128 or spectroscopy system115 can be optically coupled to the beam splitter 114, and can providespectral measurements from the optical response signal 119. Suchspectral measurements can be used to determine characteristics of thetarget such a materials, hardness, etc. which, in turn, can be used toguide the procedure. Such guidance may result in selecting a differenttool, adjusting a tool (e.g. laser setting) or combinations thereof tomore efficiently proceed with the procedure.

Spectroscopy/spectrometry techniques can be used to identify materialsor structures via the spectrum reflected, transmitted, emitted,absorbed, or not absorbed by a target surface. Optical spectroscopy canprovide timely analysis of organic and inorganic materials. Forablation, optical spectroscopy can help provide several advantages, suchas including, but not limited to, integration with fiber laser ablationtechniques, nondestructive methods of material chemical compositionanalyses, real-time or near real-time composition estimates or profiles,and applicability for analyses of different types of biologicalmaterials: hard and soft tissue, stones, and others. Spectroscopictechniques can be used alone or in combination to analyze hard or softtissue chemical composition and create digital spectral data. In someexamples, one or more types of spectroscopy, including but not limitedto, color, ultra-violet, deep ultra-violet, visual light, near-infrared,and florescent spectroscopy, can be used with the endoscope 103 toidentify the composition of target tissue 117. In an example, thespectroscopy system 112 can initiate and control the light source 104illuminating the target tissue via, for example, the first opticaltransmission media 108 of the endoscope probe 103, can receive opticalresponse signal either reflected from or generated at the target tissue117 such as via an optical transmission media of the working probe 113,and can generate spectral data based on the optical response signal 119.In certain examples, the light source 103 can include, but is notlimited to, a visible light source, an infrared light source, anultraviolet light source, a fluorescent light source, or a combinationthereof.

The feedback analyzer 116 can receive a spectroscopic response signaldelivered from the spectrometer 128, can estimate a composition orcompositions profile of the materials represented by the spectral data,and can display such estimates or provide one or more control signalsfor controlling the primary surgical instrument 102. The composition orstructure information can be useful to help provide feedback that can beused for more efficiently performing the surgical procedure. Forexample, the feedback analyzer 116 can compare the spectroscopicresponse signal with an available database library of tissue compositiondata. The feedback analyzer 116 can estimate target material compositionbased on the spectroscopic response signal and suggest a configurationfor the primary surgical instrument 102 to achieve effective tissuetreatment for the identified tissue composition. In certain examples,the feedback analyzer 116 can provide one or more control signals orcontrol data to adjust one or more parameter settings of the primarysurgical instrument 102. In a laser ablation example, the feedbackanalyzer 116 or an intermediate device, can program laser settingsautomatically based on the target material composition estimate. In someexamples, adjustment of the laser settings can be limited or constrainedto be within a set individual or multivariate safe operating range suchas based on a setting selected by the end-user at the start of theprocedure.

In certain examples, the spectroscopy system 115 can optionallycommunicate with a database 129. In some examples, the database 129 canbe a repository for measurements and other information associated with aprocedure. In some examples, as the database collects more information,the spectroscopy system 102 or a portion thereof, such as the feedbackanalyzer 116, can interact with information of the database 129 todetermine, for example, the most efficient application of the lasersystem 112 based on spectroscopic information collected or analyzedduring the procedure and compare with the historical informationavailable in the database 129. In certain examples, the database may beable to provide temporal recipe for configuration of the primarysurgical instrument 102 as the spectroscopic information of a procedureis collected and analyzed. In certain examples, the database 129 caninclude an internet-based or a cloud-based database and may includeapplications designed for interacting with a feedback analyzer 116 orsome other portion of the spectroscopy system 102 to assist in executingan efficient surgical procedure based on historical procedureinformation and adaptive to the specific spectroscopic informationcollected during the procedure.

For example, for a laser ablation system, the laser settings that can bepart of a recipe for configuration of the primary surgical instrument102 can include, but are not limited to, laser operation mode (e.g.,pulse or continuous wave), power, energy, frequency, pulse shape, pulseprofile, or one or more combinations thereof. In certain examples, thelaser system 112 can operate in an automatic mode or a semi-automaticmode among other modes. In automatic mode, the laser settings can beautomatically controlled based on the target material compositionestimate. In semi-automatic mode, the laser settings can be adjustedbased on the target material composition estimate after receiving someconfirmatory indication of operator approval for making the settingchange. The combination of the laser system 112, spectroscopy system115, and the feedback analyzer 116 can be used in an ongoingintraoperative feedback mode such as to continuously or recurrentlyidentify the composition of target tissue 117 through the working probe113 and update the laser settings during or throughout a procedure. Itis understood that other surgical techniques other than laser-basedsurgical techniques as discussed herein are possible to use with thetarget identification system 100 without departing from the scope of thepresent subject matter

In certain examples, a single optical transmission media of the workingprobe 113 of the target identification system 100 can be used totransport a first type of electromagnetic emission or beam to or fromthe target tissue 117 at the distal end 109 of the working probe 113 andcan also be used to transport an optical response signal from the distalend 109 of the working probe 113 to the spectroscopy system 115. Theoptical splitter 114 can be used to merge multiple optical pathways intoa single optical pathway or to separate optical information from acommon optical pathway to one or more separate optical pathways. Theoptical splitter 114 can make use of a wavelength sensitive coating suchan anti-reflective coating or material or a dichroic coating or materialor a combination thereof. Suitable material for anti-reflection coatingscan include SiO2 (refractive index between about 1.4 and about 1.5), SiO(refractive index between about 1.8 and about 1.9), Si3N4 (refractiveindex of about 1.9), TiO2 (refractive index of about 2.3), Ta2O5(refractive index between about 2.1 and about 2.3), MgF2 (refractiveindex between about 1.4 and about 1.5), BaF2 (refractive index of about1.47), and others.

FIG. 2 illustrates generally a detailed example of a targetidentification system 200. The target identification system 200 caninclude a beam splitter 214, a probe 113, and a spectroscopy system 215.The beam splitter 214 can include at least three ports 221, 222, 223, acollimation lens 220, a focus lens 224, and an integrating sphere 225.The three ports 221, 222, 223 can include a first port 221 for a firstoptical pathway, a second port 222 for a feedback optical pathway to thespectroscopy system, and a third port 223 for a common optical pathway130 for transmitting a first optical signal, such as a laser beam 118,and an optical response signal 119 between the beam splitter 214 and thedistal end of the probe 113. As an example, laser energy can be coupledfrom the first port 221 to the third port 223 such as via thecollimation lens 220 and the focus lens 224, and the optical responsesignal 119 can be coupled from the third port 223 to the second port 222such as via a combination of the focus lens 224 and the integratingsphere 225. The focus lens 224 can include a wavelength sensitivematerial or coating 226, such as an AR material, that can be transparentor anti-reflective to the wavelength of the laser, but highly reflectiveto wavelengths of interest of the optical response signal 119. As such,much if not all of the laser energy can be passed from the first port221 to the third port 223. The optical response signal 119 can bereceived via the third port 223 and reflected back or redirected intothe integrating sphere 225 such as by a coated surface of the focus lens224. The interior surfaces of the integrating sphere 225 can continue toredirect the optical response signal 119 around until the opticalresponse signal 119 exits the integrating sphere 225 via the second port222. Upon exiting the integrating sphere 225 via the second port 222,the optical response signal 119 can be transmitted to the spectroscopysystem.

FIG. 3 illustrates generally a detailed example of a targetidentification system 300. The target identification system 300 caninclude a beam splitter 314, a probe 113, and a spectroscopy system 315.The beam splitter 314 can include at least three ports 321, 322, 323, afocusing lens 324, and an integrating sphere 325. The three ports 321,322, 323 can include a first port 321 for a laser optical pathwaycoupled to the laser, a second port 322 for a feedback optical pathwayto the spectroscopy system, and a third port 323 for a common opticalpathway 130 for transmitting both the laser and the optical responsesignal 119 between the beam splitter 314 and the distal end of theworking probe 113. Unlike the beam splitter of FIG. 2, the focus lens324 can be designed to perform both the collimating function of thelaser light and the focusing function of the laser light to the thirdport 323. In operation, the laser energy is coupled from the first port321 to the third port 323 via the focusing lens 324 and the opticalresponse signal 119 is coupled from the third port 323 to the secondport 322 via a combination of the focusing lens 324 and the integratingsphere 325. In certain examples, the focusing lens 324 can include awavelength sensitive material or coating 326, such as an AR material,that is transparent or anti-reflective to the wavelength of the laser,but highly reflective to the wavelengths of the optical response signal119. As such, much of the laser energy is passed from the first port 321to the third port 323 while the optical response signal 119 receivedfrom the third port 323 is reflected into the integrating sphere 325.The integrating sphere 325 can continue to reflect the optical responsesignal 119 around until the image information exits the integratingsphere 325 via the second port 322. Upon exiting the integrating sphere325 via the second port 322, the optical response signal 119 can betransmitted to the spectroscopy system.

FIG. 4 illustrates generally a detailed example of a targetidentification system 400. The target identification system 400 caninclude a beam splitter 414, a probe 113, and a spectroscopy system 415.The beam splitter 414 can include two ports 421, 423, a collimation lens420, a focus lens 424, and an optical sensor 425. The two ports 421, 423can include a first port 421 for a laser optical pathway coupled to thelaser, and a second port 423 for a common optical pathway 130 fortransmitting both the laser and the optical response signal 119 betweenthe beam splitter 414 and the distal end of the working probe. Inoperation, the laser energy is coupled from the first port 421 to thethird port 423 via the collimation lens 420 and the focus lens 424. Thefocus lens 424 can include a wavelength sensitive material or coating426, such as an AR material, that is transparent or anti-reflective tothe wavelength of the laser, but highly reflective to wavelengths ofinterest of the optical response signal 119. As such, much if not all ofthe laser energy is passed from the first port 421 to the third port423. The optical response signal 119 can be received via the third port423 and reflected back or redirected to the optical sensor 425. In theexamples discussed above, the spectroscopy system typically can includean optical sensor for receiving the optical response signal 119. In thebeam splitter 414 of FIG. 4, the optical sensor 425 for receiving theoptical response signal 119 can be part of the beam splitter 414 and canform at least part of the optical pathway or optical transmission mediafor the optical response signal 119.

FIG. 5 illustrates generally a detailed example of a targetidentification system 500. The target identification system 500 caninclude a beam splitter 514, a probe 113, and a spectroscopy system 515.The beam splitter 514 can include at least three ports 521, 522, 523, acollimation lens 520, a first focus lens 524, and a dichroic mirror 526.In some examples, the beam splitter can include a second optionalfocusing lens 527. The three ports 521, 522, 523 can include a firstport 521 for a laser optical pathway coupled to the laser, a second port522 for a feedback optical pathway to the spectroscopy system, and athird port 523 for a common optical pathway 130 for transmitting boththe laser and the optical response signal 119 between the beam splitter514 and the distal end of the working probe. In operation, the laserenergy is coupled from the first port 521 to the third port 523 via thecollimation lens 520 and the first focus lens 524, and the opticalresponse signal 119 is coupled from the third port 523 to the secondport 522 via a combination of the focus lens 524 and the dichroic mirror526. The dichroic mirror 526 allows light of a certain wavelength topass through, while light of other wavelengths is reflected. In certainexamples, such as in FIG. 5, such other wavelengths can includewavelengths of the optical response signal 119. In certain examples, thedichroic mirror 526 is fabricated to pass wavelengths associated withthe laser energy and to reflect wavelengths associated with the opticalresponse signal 119. As such, the dichroic mirror 526 can extract theoptical response signal 119 from the common optical pathway 130 of thatalso includes the laser energy and divert the optical response signal119 to the spectroscopy system via the second port 522 of the beamsplitter 514. In certain examples, the focus lens 524 can include awavelength sensitive material or coating 526, such as an AR material,that is transparent or anti-reflective to the wavelength of the laser,such that much if not all of the laser energy is passed from the firstport 521 to the third port 523.

FIG. 6 illustrates generally an example of a method of operating anablation system. At 601, a working instrument can be extended through afirst lumen of a viewing instrument such as an endoscope. At 603, anarea beyond a distal end of the viewing instrument can be illuminatedvia an optical path of the viewing instrument. A light source (e.g.,FIG. 1, 104) can be located at a proximal or distal end of the viewinginstrument. The light source can be a visible light source, an infraredlight source, an ultraviolet light source, a fluorescent light source,or a combination thereof. At 605, in response to illumination of thearea, optical response information, can be received, via an optical pathof the working instrument, at a proximal end of the working instrument.The optical response information can include light reflected from targettissue in the area at the distal end of the endoscope. In certainexamples, the optical response information can include light emittedfrom or generated from the target tissue in the area at the distal endof the endoscope. At 607, the optical response signal can be separatedfrom the optical path of the working instrument such as by a beamsplitter as discussed above. In certain examples, a second opticalsignal can be transmitted via the optical path of the working at thesame time the optical response signal is being transmitted and separatedor split from the optical path of the working instrument. As an example,the second optical signal can be a laser beam. For example, a laser beamcan be passed between the proximal end of the working instrument and thearea at the distal end via the optical path of the working instrument.Thus, the single optical path of the working instrument can be anoptical transmission medium for simultaneous transmission of both thelaser beam and the optical response information.

The optical response information can be used to detect the structure andcomposition of the target tissue. For example, the optical responseinformation can be provided to a spectroscopy system. The spectroscopysystem can include a spectrometer and a spectral analyzer. Thespectrometer can provide spectral measurements of the optical responseinformation. The spectral analyzer can compare the spectral measurementsto one or more samples of expected compositions. The spectral analyzercan base an estimate the composition of the target tissue. In someexamples, and end-user of the ablation system can adjust an operatingparameter of the laser to more effectively treat the patent. Forexample, the composition estimate provided by the spectral analyzer canindicate that the target tissue currently being treated is harder orsofter than prior-treated tissue. Such information can allow theend-user to adjust, for example, an intensity of the laser to moreeffectively ablate the harder or softer target tissue. In some examples,the spectral analyzer can automatically or semi-automatically adjustoperating parameters of the laser or the light source in response to acomposition estimate.

FIG. 7 illustrates generally a detailed view of an example of a targetidentification system 700. The target identification system 700 caninclude a beam splitter 714, a working probe 113, and a spectroscopysystem 715 optically coupled to the beam splitter 714. The beam splitter714 can include at least three ports 721, 722, 723, a collimation lens720, a first focus lens 724, and a reflector 726. The reflector 726 canbe glass and may or may not have a coating. The reflector 726 caninclude an opening to allow laser light from a laser beam 118 to pass.In some examples, the beam splitter 714 can include a second optionalfocusing lens 727. The three ports 721, 722, 723 can include a firstport 721 for a laser optical pathway coupled to the laser, a second port722 for a feedback optical pathway to the spectroscopy system, and athird port 723 for a common optical pathway 130 for transmitting boththe laser and the optical response signal 119 between the beam splitter714 and the distal end of the working probe 113. In operation, the laserenergy is coupled from the first port 721 to the third port 723 via thecollimation lens 720, the opening in the reflector and the first focuslens 724. The optical response signal 119 can be coupled from the thirdport 723 to the second port 722 via a combination of the focus lens 724and the reflector 726. In certain examples, the diameter and numericalaperture of the optical pathway at the third port 723 can be larger thanthe diameter and numerical aperture of the optical pathway providing thelaser beam at the first port 721. The size relationship of the opticalports and numerical aperture can allow the optical response through thebeam splitter to be expanded farther than the optical signal of thelaser beam 118. As such, more light from the optical response can becollected without affecting the path of the laser beam compared to apath of the optical response that has less expansion.

FIG. 8 illustrates generally a detailed view of an example of a targetidentification system 800. The target identification system 800 caninclude a beam splitter 814, a working probe 113, and a spectroscopysystem 815. The beam splitter 814 can include at least three ports 821,822, 823, 832 a collimation lens 820, a first focus lens 824, and afirst reflector 826 and a second reflector 836. The reflectors 826, 836can be glass and may or may not have a coating. In some examples, thebeam splitter 814 can include a second optional focusing lenses 827,837. The four ports 821, 822, 823, 832 can include a first port 821 fora laser optical pathway coupled to the laser, a second port 822 for afirst feedback optical pathway to the spectroscopy system, a third port823 for a common optical pathway 130 for transmitting both the laser andthe optical response signal 119 between the beam splitter 814 and thedistal end of the working probe 113, and a fourth port for a secondfeedback optical pathway to the spectroscopy system. In operation, thelaser energy is coupled from the first port 821 to the third port 823via the collimation lens 820, the reflectors 826, 836, and the firstfocus lens 824. The optical response signal 119 can be coupled from thethird port 823 to the second port 822 via a combination of the focuslens 824 and the first reflector 826. The optical response signal canalso be coupled from the third port 823 to the fourth port 832 via acombination of the focus lens 824 and the second reflector 836. Thesystem can include an optical coupler 830 to couple the first and secondfeedback optical pathways to provide the optical response signal 119.The illustrated example of FIG. 8 can allow efficient coupling of thelaser beam with the common optical pathway 130 when the reflectors areglass. At the same time, having two glass reflectors can allowcollecting more energy from the response optical path than using asingle reflector, thus, resulting in a stronger optical response signal119. In certain examples, the reflectors can include an opening and canbe used a similar fashion as the lone reflector 726 in FIG. 7. Theopenings can allow the laser energy to pass unobstructed and the twoglass reflectors can capture the optical response energy from thecollimated light about the laser beam.

FIG. 9 illustrates generally a detailed view of an example of a targetidentification system 900. The target identification system 900 caninclude a beam splitter 914, a working probe 113, and a spectroscopysystem 915. The beam splitter 914 can include at least two ports 921,923, a collimation lens 920, a focus lens 924, and one or more feedbackfibers 931. The feedback fibers or multiple bundles of fibers canreceive optical response energy and provide an optical pathway for theoptical response energy or signal 919 to be received at the spectroscopysystem 915. The two ports 921, 923 can include a first port 921 for alaser optical pathway coupled to the laser, and a second port 923 for acommon optical pathway 130 for transmitting both the laser and anoptical response signal 119 between the beam splitter 914 and the distalend of the working probe 113. In operation, the laser energy is coupledfrom the first port 921 to the third port 923 via the collimation lens920, and the first focus lens 924. As discussed above, the opticalresponse signal 119 can be coupled from the third port 923 to thespectroscopy system via a combination of the focus lens 924 and thefeedback fiber(s) 931. In certain examples, the diameter and numericalaperture of the optical pathway at the second port 923 can be largerthan the diameter and numerical aperture of the optical pathwayproviding the laser beam at the first port 921. The size relationship ofthe optical ports and numerical aperture can allow the optical responsesignal 119 through the beam splitter to be expanded farther than theoptical signal of the laser beam 118. As such, more light from theoptical response can be collected without affecting the path of thelaser beam compared to a path of the optical response that has lessexpansion. In certain examples, additional feedback fibers 931 can beplaced about the collimated path of the laser between the collimationlens 920 and the focus lens 924 to collect more energy of the opticalresponse signal 919 within the optical splitter. In the extreme, anassembly of feedback fibers 931, for example, in the shape of a ring,can be placed about the path of the laser light to collect all the lightof the optical response signal.

Additional Notes

The above detailed description includes references to the accompanyingdrawings, which form a part of the detailed description. The drawingsshow, by way of illustration, specific embodiments in which theinvention can be practiced. These embodiments are also referred toherein as “examples.” Such examples can include elements in addition tothose shown or described. However, the present inventors alsocontemplate examples in which only those elements shown or described areprovided. Moreover, the present inventors also contemplate examplesusing any combination or permutation of those elements shown ordescribed (or one or more aspects thereof), either with respect to aparticular example (or one or more aspects thereof), or with respect toother examples (or one or more aspects thereof) shown or describedherein.

In this document, the terms “a” or “an” are used, as is common in patentdocuments, to include one or more than one, independent of any otherinstances or usages of “at least one” or “one or more.” In thisdocument, the term “or” is used to refer to a nonexclusive or, such that“A or B” includes “A but not B,” “B but not A,” and “A and B,” unlessotherwise indicated. In this document, the terms “including” and “inwhich” are used as the plain-English equivalents of the respective terms“comprising” and “wherein.” Also, in the following claims, the terms“including” and “comprising” are open-ended, that is, a system, device,article, composition, formulation, or process that includes elements inaddition to those listed after such a term in a claim are still deemedto fall within the scope of that claim. Moreover, in the followingclaims, the terms “first,” “second,” and “third,” etc. are used merelyas labels, and are not intended to impose numerical requirements ontheir objects.

The above description is intended to be illustrative, and notrestrictive. For example, the above-described examples (or one or moreaspects thereof) may be used in combination with each other. Otherembodiments can be used, such as by one of ordinary skill in the artupon reviewing the above description. The Abstract is provided to complywith 37 C.F.R. § 1.72(b), to allow the reader to quickly ascertain thenature of the technical disclosure. It is submitted with theunderstanding that it will not be used to interpret or limit the scopeor meaning of the claims. Also, in the above Detailed Description,various features may be grouped together to streamline the disclosure.This should not be interpreted as intending that an unclaimed disclosedfeature is essential to any claim. Rather, inventive subject matter maylie in less than all features of a particular disclosed embodiment.Thus, the following claims are hereby incorporated into the DetailedDescription as examples or embodiments, with each claim standing on itsown as a separate embodiment, and it is contemplated that suchembodiments can be combined with each other in various combinations orpermutations. The scope of the invention should be determined withreference to the appended claims, along with the full scope ofequivalents to which such claims are entitled.

What is claimed is:
 1. A target identification system comprising: aprobe having a first end and a second end, the second end configured tolocate adjacent an anatomical target, the probe configured to define anoptical path, the optical path configured to simultaneously pass a firstoptical signal and a second optical signal representative of theanatomical target; and a beam splitter comprising: a first port coupledto the first end of the probe; a second port configured to align withthe optical path and configured to pass the first optical signal; andwherein the beam splitter is configured to redirect the second opticalsignal representative of the anatomical target from the optical path andfrom the first optical signal.
 2. The target identification system ofclaim 1, including a spectrometer optically coupled to the beamsplitter, the spectrometer configured to receive from the beam splitterthe second optical signal representative of the anatomical target and toprovide spectral measurements representative of the anatomical target.3. The target identification system of claim 2, including a feedbackanalyzer configured to receive the spectral measurements and to generatea composition profile of the target.
 4. The target identification systemof claim 2, wherein the beam splitter includes: a focusing lens; anoptical sensor; and wherein the focusing lens includes a wavelengthsensitive layer, the wavelength sensitive layer configured to pass thefirst optical signal along the optical path and to redirect the secondoptical signal toward the optical sensor.
 5. The target identificationsystem of claim 4, wherein the optical sensor is configured to couple tothe spectrometer and to convert the second optical signal to one or moreelectrical signals.
 6. The target identification system of claim 2,wherein the beam splitter includes: a focusing lens having a wavelengthsensitive layer, the wavelength sensitive layer configured to pass thefirst optical signal along the optical path and to redirect the secondoptical signal; a third optical port coupled to spectroscopic system;and an integrating sphere configured to further redirect the secondoptical signal to the third optical port.
 7. The target identificationsystem of claim 2, wherein the beam splitter includes: a third opticalport; and a dichroic mirror configured to pass the first optical signalfrom the first port to the second port, and to redirect the secondoptical signal to a third optical port.
 8. A surgical system comprising:a viewing instrument including a lumen, the viewing instrument and thelumen defining a proximal end and a distal end, the viewing instrumentcomprising a light source configured to illuminate an anatomical targetvia an optical path of the viewing instrument; and a targetidentification system comprising: a working probe configured to extendthrough the lumen; a beam splitter coupled to a proximal end of theworking probe, the beam splitter configured to split an optical responsesignal indicative of the target from the optical path; and aspectrometer optically coupled to the beam splitter, the spectrometerconfigured to receive from the beam splitter at least a representationof the optical response signal and provide spectral measurementsrepresentative of the anatomical target.
 9. The surgical system of claim8, wherein the beam splitter includes: a first port coupled to theproximal end of the probe; and a second port configured to align withthe optical path and configured to pass a second optical signal.
 10. Thesurgical system of claim 9, wherein the beam splitter includes: afocusing lens; an optical sensor; and wherein the focusing lens includesa wavelength sensitive layer, the wavelength sensitive layer configuredto pass the second optical signal along the optical path and to redirectthe optical response signal toward the optical sensor.
 11. The surgicalsystem of claim 10, wherein the optical sensor is configured to coupleto the spectrometer and to convert the optical response signal to one ormore electrical signals.
 12. The surgical system of claim 9, wherein thebeam splitter includes: a focusing lens in a path of the optical path,the focusing lens including a wavelength sensitive layer, the wavelengthsensitive layer configured to pass the second optical signal along theoptical path and to redirect the optical response signal to provide aredirected optical response signal; a third optical port coupled tospectrometer; and an integrating sphere configured to reflect theredirected optical response signal to the third optical port.
 13. Thesurgical system of claim 9, wherein the beam splitter includes: a thirdoptical port coupled to the spectrometer; and a dichroic mirrorconfigured to pass the second optical signal along the optical path, andto reflect the optical response signal to the third optical port. 14.The surgical system of claim 8, wherein the target identification systemincludes a feedback analyzer configured to receive spectral informationand to generate a composition profile of the target.
 15. The surgicalsystem of claim 14, including a procedure instrument configured toutilize the working probe contemporaneously with the optical responsesignal transiting the optical path; and wherein the feedback analyzer isconfigured to provide control signals to the procedure instrument basedon the composition profile.
 16. The surgical system of claim 15, whereinthe procedure instrument includes a laser configured to generate a laserbeam, the laser beam configure to transit the optical path from the beamsplitter to the distal end of the probe contemporaneously with theoptical response signal transiting the optical path.
 17. A laser surgerysystem comprising: a laser system configured to generate a laser beamoperable to ablate a target within a patient's body; an optical probecomprising: an optical fiber configured to transmit the laser beam tothe target and to transmit target light from the target; and a beamsplitter configured to pass the laser beam from the laser system to theoptical fiber and to receive the target light and split the target lightfrom the laser beam; a spectrometer optically coupled to the beamsplitter, the spectrometer configured to receive the target light splitfrom the laser beam and to generate spectral information of the targetlight; and feedback circuitry configured to receive the spectralinformation and determine composition information of the target.
 18. Thelaser surgery of claim 17, wherein the laser system is configured toreceive the composition information and to adjust the laser beamresponsive to the composition information.
 19. A method comprising:extending a working instrument via a first lumen of a viewinginstrument; illuminating an anatomical target via an optical path of theviewing instrument; passing an optical response signal of the anatomicaltarget via an optical path of the working instrument; and splitting theoptical response signal from the optical path of the working instrument.20. The method of claim 19, wherein the viewing instrument is anendoscope.
 21. The method of claim 19, wherein the viewing instrument isa laparoscope.
 22. The method of claim 19, including passing the opticalresponse signal to a spectroscopy system.
 23. The method of claim 19,including passing a second optical signal via the optical path of theworking instrument at while passing the optical response signal.
 24. Themethod of claim 23, wherein the second optical signal is a laser beamconfigured to ablate the anatomical target.
 25. The method of claim 24,wherein passing the optical response signal to a spectroscopy systemincludes splitting the optical response from the optical path of theworking instrument to a third optical path.
 26. The method of claim 25,wherein passing the laser beam includes merging an optical pathextending from the laser with the optical path of the workinginstrument.
 27. The method of claim 26, wherein merging an optical pathextending from the laser includes passing the laser beam through adichroic mirror; and wherein splitting the optical response from theoptical path of the working instrument includes reflecting the opticalresponse a surface of the dichroic mirror.